| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Eagle | city | South Dakota | United States | 43.57 | -99.09 | 1748 | |
| Eagle Butte | city | South Dakota | United States | 45.00 | -101.23 | 2509 | |
| Eakin | city | South Dakota | United States | 44.62 | -100.03 | 1781 | |
| East Sioux Falls | city | South Dakota | United States | 43.53 | -96.61 | 1669 | |
| Eden | city | South Dakota | United States | 45.62 | -97.42 | 1847 | |
| Edgemont | city | South Dakota | United States | 43.30 | -103.83 | 3592 | |
| Egan | city | South Dakota | United States | 44.00 | -96.65 | 1669 | |
| El Rancho Acres | city | South Dakota | United States | 43.50 | -96.87 | 1669 | |
| Elbon | city | South Dakota | United States | 44.28 | -101.69 | 2529 | |
| Elevenmile Corner | city | South Dakota | United States | 44.20 | -101.67 | 2509 | |
| Elizabethtown (historical) | city | South Dakota | United States | 44.39 | -103.70 | 5029 | |
| Elk Point | city | South Dakota | United States | 42.68 | -96.68 | 1125 | |
| Elkton | city | South Dakota | United States | 44.24 | -96.48 | 1751 | |
| Ellingson (historical) | city | South Dakota | United States | 45.87 | -102.87 | 2700 | |
| Ellis | city | South Dakota | United States | 43.56 | -96.83 | 1669 | |
| Ellis Corner | city | South Dakota | United States | 43.60 | -96.83 | 1669 | |
| Elm Springs | city | South Dakota | United States | 44.31 | -102.53 | 2627 | |
| Elmore | city | South Dakota | United States | 44.32 | -103.89 | 5869 | |
| Elrod | city | South Dakota | United States | 44.89 | -97.57 | 1804 | |
| Emery | city | South Dakota | United States | 43.60 | -97.62 | 1669 | |
| Emmet | city | South Dakota | United States | 42.98 | -96.75 | 1669 | |
| Empire | city | South Dakota | United States | 44.62 | -103.32 | 2798 | |
| Englewood | city | South Dakota | United States | 44.30 | -103.78 | 5997 | |
| Enning | city | South Dakota | United States | 44.58 | -102.56 | 3349 | |
| Epiphany | city | South Dakota | United States | 43.85 | -97.66 | 1669 | |
| Erickson Subdivision | city | South Dakota | United States | 43.61 | -96.71 | 1669 | |
| Erskine | city | South Dakota | United States | 43.43 | -103.56 | 4189 | |
| Erwin | city | South Dakota | United States | 44.49 | -97.45 | 1833 | |
| Esmond | city | South Dakota | United States | 44.26 | -97.77 | 1669 | |
| Estelline | city | South Dakota | United States | 44.57 | -96.90 | 1679 | |
| Ethan | city | South Dakota | United States | 43.55 | -97.99 | 1669 | |
| Eureka | city | South Dakota | United States | 45.77 | -99.62 | 1889 | |
| Evergreen | city | South Dakota | United States | 43.31 | -102.36 | 3349 | |
| Evergreen Colony | city | South Dakota | United States | 45.12 | -99.04 | 1669 |