| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Stafford | city | South Carolina | United States | 32.67 | -81.16 | 104 | |
| Stafford Heights | city | South Carolina | United States | 32.72 | -80.07 | 9 | |
| Staley Crossroads | city | South Carolina | United States | 33.67 | -80.96 | 351 | |
| Stallsville | city | South Carolina | United States | 33.00 | -80.18 | 68 | |
| Stalnaker Heights | city | South Carolina | United States | 34.22 | -82.15 | 830 | |
| Stalvey | city | South Carolina | United States | 33.69 | -78.97 | 19 | |
| Star Bluff Crossroads | city | South Carolina | United States | 33.86 | -78.76 | 36 | |
| Starlite | city | South Carolina | United States | 33.94 | -80.97 | 141 | |
| Starmount | city | South Carolina | United States | 33.92 | -81.07 | 187 | |
| Starmount Acres | city | South Carolina | United States | 34.68 | -80.80 | 830 | |
| Starr | city | South Carolina | United States | 34.38 | -82.70 | 830 | |
| Starsdale Manor | city | South Carolina | United States | 34.92 | -82.42 | 1000 | |
| Startex | city | South Carolina | United States | 34.93 | -82.10 | 830 | |
| State Farm (historical) | city | South Carolina | United States | 34.10 | -80.58 | 137 | |
| State Line | city | South Carolina | United States | 35.18 | -81.80 | 948 | |
| State Park | city | South Carolina | United States | 34.09 | -80.97 | 298 | |
| State Park Acres | city | South Carolina | United States | 34.12 | -80.94 | 308 | |
| Stateburg | city | South Carolina | United States | 33.96 | -80.53 | 282 | |
| Staunton Heights | city | South Carolina | United States | 34.81 | -82.44 | 971 | |
| Stave Landing | city | South Carolina | United States | 34.18 | -79.19 | 39 | |
| Steamboat Landing | city | South Carolina | United States | 32.60 | -80.29 | 9 | |
| Steedman | city | South Carolina | United States | 33.78 | -81.44 | 308 | |
| Steel Creek Landing | city | South Carolina | United States | 33.10 | -81.61 | 78 | |
| Steele Crossing | city | South Carolina | United States | 34.91 | -81.06 | 830 | |
| Steele Town | city | South Carolina | United States | 33.37 | -79.29 | 3 | |
| Steep Bottom (historical) | city | South Carolina | United States | 32.70 | -81.21 | 111 | |
| Stephens Crossroads | city | South Carolina | United States | 33.88 | -78.69 | 39 | |
| Stewart Crossroads | city | South Carolina | United States | 34.80 | -80.60 | 830 | |
| Stiefeltown | city | South Carolina | United States | 33.55 | -81.80 | 354 | |
| Stiles Point | city | South Carolina | United States | 32.74 | -79.92 | 13 | |
| Stilton | city | South Carolina | United States | 33.54 | -80.84 | 272 | |
| Stockton (historical) | city | South Carolina | United States | 34.15 | -80.57 | 157 | |
| Stokes | city | South Carolina | United States | 33.77 | -80.35 | 180 | |
| Stokes | city | South Carolina | United States | 32.96 | -80.73 | 65 | |
| Stokes | city | South Carolina | United States | 32.64 | -81.17 | 98 | |
| Stokes (historical) | city | South Carolina | United States | 33.02 | -80.00 | 26 | |
| Stokes Bluff Landing | city | South Carolina | United States | 32.56 | -81.28 | 22 | |
| Stomp Springs | city | South Carolina | United States | 34.47 | -81.73 | 830 | |
| Stone Creek | city | South Carolina | United States | 35.00 | -82.02 | 866 | |
| Stone Gap | city | South Carolina | United States | 33.50 | -81.77 | 830 | |
| Stone Haven | city | South Carolina | United States | 34.71 | -82.87 | 830 | |
| Stone Haven Mobile Home Park | city | South Carolina | United States | 34.92 | -81.89 | 830 | |
| Stone Lake | city | South Carolina | United States | 34.87 | -82.38 | 944 | |
| Stone Lake Heights | city | South Carolina | United States | 34.88 | -82.37 | 997 | |
| Stone Park | city | South Carolina | United States | 32.78 | -80.02 | 6 | |
| Stone Station | city | South Carolina | United States | 34.85 | -81.93 | 830 | |
| Stoneboro | city | South Carolina | United States | 34.54 | -80.74 | 830 | |
| Stonehaven | city | South Carolina | United States | 34.54 | -82.73 | 830 | |
| Stoneledge | city | South Carolina | United States | 34.84 | -82.28 | 954 | |
| Stonewall Woods | city | South Carolina | United States | 34.56 | -82.70 | 830 | |
| Stoney Hill | city | South Carolina | United States | 34.17 | -81.57 | 830 | |
| Stoneybrook Estates | city | South Carolina | United States | 34.91 | -81.02 | 830 | |
| Stono | city | South Carolina | United States | 32.73 | -79.98 | 3 | |
| Stono Station | city | South Carolina | United States | 32.76 | -80.11 | 16 | |
| Stony Landing | city | South Carolina | United States | 33.19 | -79.97 | 13 | |
| Stony Point | city | South Carolina | United States | 34.28 | -82.13 | 830 | |
| Storeville (historical) | city | South Carolina | United States | 34.36 | -82.58 | 830 | |
| Storm Branch Park | city | South Carolina | United States | 33.48 | -81.89 | 200 | |
| Stover | city | South Carolina | United States | 34.55 | -81.02 | 830 | |
| Stratford Forest | city | South Carolina | United States | 33.02 | -80.06 | 32 | |
| Stratford Forest | city | South Carolina | United States | 34.94 | -82.45 | 1000 | |
| Stratford Terrace | city | South Carolina | United States | 34.54 | -82.65 | 830 | |
| Strathaven Forest | city | South Carolina | United States | 33.98 | -80.92 | 249 | |
| Stratton Capers | city | South Carolina | United States | 32.93 | -80.10 | 29 | |
| Stratton Place | city | South Carolina | United States | 34.87 | -82.32 | 1003 | |
| Strawberry | city | South Carolina | United States | 33.09 | -80.03 | 26 | |
| Strawberry | city | South Carolina | United States | 33.33 | -79.25 | 13 | |
| Strawberry Landing | city | South Carolina | United States | 33.09 | -79.94 | 3 | |
| Stringfellow | city | South Carolina | United States | 34.74 | -81.18 | 830 | |
| Strother | city | South Carolina | United States | 34.39 | -81.39 | 278 | |
| Stuart Heights | city | South Carolina | United States | 35.09 | -81.63 | 830 | |
| Stuckey | city | South Carolina | United States | 33.73 | -79.51 | 52 | |
| Sturgis Estates | city | South Carolina | United States | 34.93 | -80.98 | 830 | |
| Styx (historical) | city | South Carolina | United States | 33.91 | -81.12 | 200 |