| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Pocalla Springs | city | South Carolina | United States | 33.87 | -80.35 | 124 | |
| Pocotaligo | city | South Carolina | United States | 32.64 | -80.86 | 16 | |
| Poinsett | city | South Carolina | United States | 34.86 | -82.44 | 977 | |
| Poinsettia | city | South Carolina | United States | 34.73 | -82.24 | 830 | |
| Point Comfort | city | South Carolina | United States | 32.16 | -80.78 | 9 | |
| Point Comfort Woods | city | South Carolina | United States | 32.17 | -80.78 | 9 | |
| Point Park Estates | city | South Carolina | United States | 32.74 | -80.11 | 9 | |
| Point Pleasant | city | South Carolina | United States | 32.82 | -79.86 | 13 | |
| Point Pleasant (historical) | city | South Carolina | United States | 32.75 | -80.15 | 3 | |
| Points North | city | South Carolina | United States | 34.96 | -82.42 | 1095 | |
| Polecat Bay (historical) | city | South Carolina | United States | 33.95 | -79.08 | 75 | |
| Polecat Landing | city | South Carolina | United States | 34.08 | -79.25 | 39 | |
| Polk Village | city | South Carolina | United States | 32.44 | -80.70 | 3 | |
| Polly Landing | city | South Carolina | United States | 33.51 | -80.43 | 72 | |
| Polson Crossroads | city | South Carolina | United States | 34.30 | -80.02 | 200 | |
| Pomaria | city | South Carolina | United States | 34.27 | -81.42 | 347 | |
| Pond Town | city | South Carolina | United States | 32.92 | -81.14 | 118 | |
| Ponderosa | city | South Carolina | United States | 32.80 | -80.09 | 3 | |
| Ponderosa | city | South Carolina | United States | 34.75 | -82.23 | 830 | |
| Ponderosa | city | South Carolina | United States | 34.18 | -79.74 | 118 | |
| Ponderosa Gardens | city | South Carolina | United States | 34.91 | -81.85 | 830 | |
| Ponderosa Heights | city | South Carolina | United States | 34.24 | -82.20 | 830 | |
| Ponpon | city | South Carolina | United States | 32.76 | -80.43 | 9 | |
| Pontiac | city | South Carolina | United States | 34.13 | -80.85 | 357 | |
| Pope Crossroads | city | South Carolina | United States | 33.70 | -79.30 | 22 | |
| Poplar Acres | city | South Carolina | United States | 35.00 | -81.22 | 830 | |
| Poplar Cove | city | South Carolina | United States | 34.64 | -82.88 | 830 | |
| Poplar Forks | city | South Carolina | United States | 33.93 | -79.03 | 68 | |
| Poplar Hill | city | South Carolina | United States | 33.73 | -79.45 | 49 | |
| Poplar Hill | city | South Carolina | United States | 33.99 | -79.10 | 98 | |
| Poplar Spring | city | South Carolina | United States | 33.49 | -80.95 | 269 | |
| Poplar Springs | city | South Carolina | United States | 34.87 | -82.05 | 830 | |
| Poplar Springs | city | South Carolina | United States | 34.44 | -82.21 | 830 | |
| Poplar Springs Ridge | city | South Carolina | United States | 34.70 | -83.03 | 830 | |
| Poppenheim Crossing | city | South Carolina | United States | 32.97 | -80.00 | 26 | |
| Porcher Bluff | city | South Carolina | United States | 32.86 | -79.76 | 3 | |
| Port Bass | city | South Carolina | United States | 34.51 | -83.07 | 830 | |
| Port Harrelson (historical) | city | South Carolina | United States | 33.68 | -79.12 | 16 | |
| Port Hill | city | South Carolina | United States | 33.72 | -79.29 | 22 | |
| Port Hill Landing | city | South Carolina | United States | 33.72 | -79.29 | 19 | |
| Port Royal | city | South Carolina | United States | 32.38 | -80.69 | 3 | |
| Port Royal Landing | city | South Carolina | United States | 32.40 | -80.68 | 3 | |
| Port Royal Plantation | city | South Carolina | United States | 32.22 | -80.67 | 0 | |
| Port Santorini | city | South Carolina | United States | 34.71 | -82.97 | 830 | |
| Possum Corner | city | South Carolina | United States | 32.68 | -80.98 | 68 | |
| Possum Town | city | South Carolina | United States | 33.39 | -80.35 | 114 | |
| Post Foot Landing | city | South Carolina | United States | 33.51 | -79.30 | 13 | |
| Poston | city | South Carolina | United States | 33.87 | -79.43 | 49 | |
| Poston Crossroads | city | South Carolina | United States | 33.90 | -79.55 | 49 | |
| Poverty Hill | city | South Carolina | United States | 33.56 | -82.01 | 295 | |
| Powderhorn | city | South Carolina | United States | 34.73 | -82.24 | 830 | |
| Powdersville | city | South Carolina | United States | 34.79 | -82.49 | 935 | |
| Powers Shop (historical) | city | South Carolina | United States | 34.64 | -82.15 | 830 |