| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Sibleyville | city | Pennsylvania | United States | 41.98 | -80.05 | 1236 | |
| Sickler Hill | city | Pennsylvania | United States | 41.23 | -75.98 | 830 | |
| Sickles Corner | city | Pennsylvania | United States | 40.55 | -78.28 | 1256 | |
| Siddonsburg | city | Pennsylvania | United States | 40.15 | -76.97 | 830 | |
| Sidley | city | Pennsylvania | United States | 40.07 | -75.56 | 328 | |
| Sidman | city | Pennsylvania | United States | 40.33 | -78.74 | 1728 | |
| Sidney | city | Pennsylvania | United States | 40.88 | -78.81 | 1683 | |
| Sierra View | city | Pennsylvania | United States | 41.01 | -75.46 | 1830 | |
| Sigel | city | Pennsylvania | United States | 41.28 | -79.11 | 1794 | |
| Siglerville | city | Pennsylvania | United States | 40.74 | -77.53 | 830 | |
| Sigmund | city | Pennsylvania | United States | 40.47 | -75.56 | 830 | |
| Sigsbee | city | Pennsylvania | United States | 39.83 | -79.96 | 898 | |
| Siko | city | Pennsylvania | United States | 41.67 | -75.25 | 1669 | |
| Siles | city | Pennsylvania | United States | 40.16 | -74.97 | 134 | |
| Silkworth | city | Pennsylvania | United States | 41.27 | -76.09 | 1197 | |
| Silvara | city | Pennsylvania | United States | 41.70 | -76.13 | 938 | |
| Silver Creek | city | Pennsylvania | United States | 40.73 | -76.13 | 882 | |
| Silver Ford Heights | city | Pennsylvania | United States | 40.38 | -77.85 | 830 | |
| Silver Mills | city | Pennsylvania | United States | 39.76 | -78.36 | 830 | |
| Silver Spring | city | Pennsylvania | United States | 40.06 | -76.44 | 830 | |
| Silver Spring | city | Pennsylvania | United States | 41.30 | -74.85 | 830 | |
| Silverbrook Farms | city | Pennsylvania | United States | 40.27 | -75.48 | 200 | |
| Silverdale | city | Pennsylvania | United States | 40.35 | -75.27 | 830 | |
| Silverton | city | Pennsylvania | United States | 40.66 | -76.27 | 1197 | |
| Silvertown (historical) | city | Pennsylvania | United States | 40.26 | -75.82 | 285 | |
| Silverville | city | Pennsylvania | United States | 40.70 | -79.72 | 1056 | |
| Simmonstown | city | Pennsylvania | United States | 39.98 | -75.99 | 830 | |
| Simpson | city | Pennsylvania | United States | 41.59 | -75.49 | 1669 | |
| Simpson | city | Pennsylvania | United States | 41.84 | -78.59 | 2509 | |
| Simpson Store | city | Pennsylvania | United States | 39.98 | -80.40 | 1669 | |
| Singersville | city | Pennsylvania | United States | 40.38 | -76.91 | 938 | |
| Sinking Spring | city | Pennsylvania | United States | 40.33 | -76.01 | 354 | |
| Sinking Spring Terrace | city | Pennsylvania | United States | 40.31 | -76.03 | 830 | |
| Sinnemahoning | city | Pennsylvania | United States | 41.32 | -78.10 | 1669 | |
| Sinsheim | city | Pennsylvania | United States | 39.80 | -76.87 | 830 | |
| Siousca | city | Pennsylvania | United States | 40.00 | -75.82 | 830 | |
| Sipes Mill | city | Pennsylvania | United States | 39.91 | -78.15 | 830 | |
| Sipesville | city | Pennsylvania | United States | 40.10 | -79.09 | 2096 | |
| Sistersville | city | Pennsylvania | United States | 40.79 | -79.61 | 1669 | |
| Sitka | city | Pennsylvania | United States | 39.99 | -79.61 | 997 | |
| Siverly | city | Pennsylvania | United States | 41.42 | -79.69 | 997 | |
| Six Mile Run Post Office (historical) | city | Pennsylvania | United States | 40.17 | -78.22 | 1669 | |
| Six Points | city | Pennsylvania | United States | 41.14 | -79.75 | 1669 | |
| Sizerville | city | Pennsylvania | United States | 41.59 | -78.20 | 1197 |