| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Sabula | city | Iowa | United States | 42.07 | -90.17 | 830 | |
| Sac City | city | Iowa | United States | 42.42 | -94.99 | 1210 | |
| Sac City Junction (historical) | city | Iowa | United States | 42.27 | -95.07 | 1243 | |
| Sageville | city | Iowa | United States | 42.55 | -90.71 | 830 | |
| Saint Ansgar | city | Iowa | United States | 43.38 | -92.92 | 1158 | |
| Saint Anthony | city | Iowa | United States | 42.12 | -93.19 | 977 | |
| Saint Benedict | city | Iowa | United States | 43.04 | -94.06 | 1249 | |
| Saint Charles | city | Iowa | United States | 41.29 | -93.81 | 1056 | |
| Saint Donatus | city | Iowa | United States | 42.36 | -90.54 | 830 | |
| Saint John Lutheran Church | city | Iowa | United States | 43.34 | -96.00 | 1669 | |
| Saint Joseph | city | Iowa | United States | 42.91 | -94.23 | 1112 | |
| Saint Lucas | city | Iowa | United States | 43.07 | -91.93 | 1112 | |
| Saint Marys | city | Iowa | United States | 41.31 | -93.73 | 1003 | |
| Saint Olaf | city | Iowa | United States | 42.93 | -91.39 | 885 | |
| Saint Paul | city | Iowa | United States | 40.77 | -91.52 | 830 | |
| Saint Sebald | city | Iowa | United States | 42.74 | -91.55 | 1099 | |
| Salem | city | Iowa | United States | 40.85 | -91.62 | 830 | |
| Salina | city | Iowa | United States | 41.05 | -91.83 | 830 | |
| Salix | city | Iowa | United States | 42.31 | -96.29 | 1082 | |
| Samoa | city | Iowa | United States | 42.08 | -90.20 | 830 | |
| Sanborn | city | Iowa | United States | 43.18 | -95.66 | 1669 | |
| Sand Bar Beach Resort and Trailer Court | city | Iowa | United States | 43.49 | -95.05 | 1669 | |
| Sand Springs | city | Iowa | United States | 42.32 | -91.19 | 902 | |
| Sandusky | city | Iowa | United States | 40.46 | -91.39 | 830 | |
| Sandusky Mobile Home Villa | city | Iowa | United States | 40.47 | -91.39 | 830 | |
| Sandyville | city | Iowa | United States | 41.37 | -93.39 | 849 | |
| Santiago | city | Iowa | United States | 41.71 | -93.37 | 898 | |
| Saratoga | city | Iowa | United States | 43.37 | -92.41 | 1243 | |
| Sattre | city | Iowa | United States | 43.39 | -91.64 | 1053 | |
| Saude | city | Iowa | United States | 43.20 | -92.16 | 1184 | |
| Savannah | city | Iowa | United States | 40.62 | -92.45 | 905 | |
| Sawyer | city | Iowa | United States | 40.70 | -91.36 | 830 | |
| Saxon | city | Iowa | United States | 40.75 | -93.46 | 1105 | |
| Saylor | city | Iowa | United States | 41.67 | -93.60 | 941 | |
| Saylor Station | city | Iowa | United States | 41.68 | -93.60 | 951 | |
| Saylorville | city | Iowa | United States | 41.68 | -93.63 | 846 |