| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Spa (historical) | city | California | United States | 35.94 | -119.44 | 226 | |
| Spadra | city | California | United States | 34.05 | -117.80 | 853 | |
| Spalding Corner | city | California | United States | 41.13 | -121.58 | 3398 | |
| Spalding Tract | city | California | United States | 40.65 | -120.77 | 5104 | |
| Spangler | city | California | United States | 35.55 | -117.45 | 2027 | |
| Spanish Flat | city | California | United States | 38.54 | -122.22 | 830 | |
| Spanish Flat | city | California | United States | 38.82 | -120.81 | 2509 | |
| Spanish Flat Resort | city | California | United States | 38.52 | -122.21 | 830 | |
| Spanish Hills | city | California | United States | 34.23 | -119.09 | 396 | |
| Spanish Ranch | city | California | United States | 39.95 | -121.06 | 4189 | |
| Spanish Ranch Mobile Home Park | city | California | United States | 37.63 | -122.06 | 187 | |
| Sparkle | city | California | United States | 37.93 | -122.06 | 187 | |
| Sparkville (historical) | city | California | United States | 36.97 | -119.61 | 830 | |
| Sparr Heights | city | California | United States | 34.20 | -118.23 | 1197 | |
| Spear Creek Summer Home Tract | city | California | United States | 35.82 | -118.59 | 6709 | |
| Spellacy | city | California | United States | 35.11 | -119.47 | 1669 | |
| Spence | city | California | United States | 36.61 | -121.57 | 82 | |
| Sperry | city | California | United States | 35.74 | -116.22 | 830 | |
| Spicer City | city | California | United States | 35.50 | -119.60 | 328 | |
| Spinks Corner | city | California | United States | 36.21 | -119.23 | 305 | |
| Spoonbill | city | California | United States | 38.06 | -121.90 | 3 | |
| Spreckels | city | California | United States | 36.62 | -121.65 | 49 | |
| Spreckels Junction | city | California | United States | 36.66 | -121.63 | 65 | |
| Sprekelsville | city | California | United States | 38.63 | -120.98 | 997 | |
| Spring Creek | city | California | United States | 38.93 | -120.06 | 6709 | |
| Spring Gap | city | California | United States | 38.17 | -120.10 | 5029 | |
| Spring Garden | city | California | United States | 39.89 | -120.79 | 4189 | |
| Spring Hill | city | California | United States | 39.23 | -121.04 | 2618 | |
| Spring Valley | city | California | United States | 38.78 | -120.53 | 4199 | |
| Spring Valley | city | California | United States | 32.74 | -117.00 | 830 | |
| Spring Valley Lake | city | California | United States | 34.49 | -117.27 | 2765 | |
| Springfield | city | California | United States | 38.02 | -120.41 | 2509 | |
| Springfield Meadows | city | California | United States | 38.65 | -121.07 | 830 | |
| Springville | city | California | United States | 36.13 | -118.82 | 1053 | |
| Springville | city | California | United States | 34.22 | -119.10 | 78 | |
| Spruce (historical) | city | California | United States | 39.32 | -120.43 | 6709 | |
| Spruce Point | city | California | United States | 40.74 | -124.20 | 134 | |
| Spyrock | city | California | United States | 39.88 | -123.44 | 830 |