| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Saint Charles | city | South Dakota | United States | 43.09 | -99.10 | 2073 | |
| Saint Francis | city | South Dakota | United States | 43.14 | -100.91 | 3349 | |
| Saint Lawrence | city | South Dakota | United States | 44.52 | -98.94 | 1669 | |
| Saint Onge | city | South Dakota | United States | 44.55 | -103.72 | 3464 | |
| Salem | city | South Dakota | United States | 43.72 | -97.39 | 1669 | |
| Sanator | city | South Dakota | United States | 43.70 | -103.61 | 5396 | |
| Sand Hill Subdivision | city | South Dakota | United States | 43.70 | -98.05 | 1669 | |
| Sansarc | city | South Dakota | United States | 44.51 | -101.03 | 2509 | |
| Savoy | city | South Dakota | United States | 44.35 | -103.93 | 5180 | |
| Saybrook (historical) | city | South Dakota | United States | 42.94 | -97.14 | 1187 | |
| Scenic | city | South Dakota | United States | 43.78 | -102.55 | 2808 | |
| Schaeferville | city | South Dakota | United States | 44.12 | -103.30 | 3553 | |
| Schmidt Landing | city | South Dakota | United States | 45.38 | -96.56 | 964 | |
| Scotland | city | South Dakota | United States | 43.15 | -97.72 | 1669 | |
| Selby | city | South Dakota | United States | 45.51 | -100.03 | 1899 | |
| Seneca | city | South Dakota | United States | 45.06 | -99.51 | 1893 | |
| Sevenmile Corner | city | South Dakota | United States | 43.84 | -101.66 | 2509 | |
| Shadehill | city | South Dakota | United States | 45.77 | -102.18 | 2509 | |
| Shady Beach | city | South Dakota | United States | 45.40 | -96.63 | 1056 | |
| Shamrock Colony | city | South Dakota | United States | 44.62 | -97.96 | 1669 | |
| Shannon Colony | city | South Dakota | United States | 43.98 | -97.42 | 1669 | |
| Sharps Corner | city | South Dakota | United States | 43.39 | -102.40 | 3349 | |
| Shaw (historical) | city | South Dakota | United States | 43.08 | -97.16 | 1669 | |
| Sheffield | city | South Dakota | United States | 44.41 | -98.07 | 1669 | |
| Shelby | city | South Dakota | United States | 43.95 | -99.19 | 1669 | |
| Sheldon Trailor Town | city | South Dakota | United States | 44.27 | -96.82 | 1669 | |
| Sheridan (historical) | city | South Dakota | United States | 43.98 | -103.47 | 5029 | |
| Sherman | city | South Dakota | United States | 43.76 | -96.48 | 1669 | |
| Shindler | city | South Dakota | United States | 43.47 | -96.65 | 1669 | |
| Silver City | city | South Dakota | United States | 44.08 | -103.56 | 5029 | |
| Silver Lake Colony | city | South Dakota | United States | 44.88 | -97.62 | 1797 | |
| Silver Valley Addition | city | South Dakota | United States | 43.53 | -96.81 | 1669 | |
| Sinai | city | South Dakota | United States | 44.24 | -97.04 | 1735 | |
| Sioux Falls | city | South Dakota | United States | 43.55 | -96.70 | 1669 | |
| Sioux Falls Junction | city | South Dakota | United States | 43.98 | -96.69 | 1669 | |
| Sioux Village | city | South Dakota | United States | 44.11 | -103.22 | 3349 | |
| Sisseton | city | South Dakota | United States | 45.66 | -97.05 | 1200 | |
| Sitka | city | South Dakota | United States | 45.52 | -100.19 | 1899 | |
| Skyline Heights | city | South Dakota | United States | 43.61 | -96.76 | 1669 | |
| Slim Butte | city | South Dakota | United States | 43.08 | -102.82 | 3349 | |
| Smiths Park | city | South Dakota | United States | 43.93 | -97.00 | 1669 | |
| Smithwick | city | South Dakota | United States | 43.30 | -103.22 | 3349 | |
| Snake Creek | city | South Dakota | United States | 45.58 | -100.59 | 1699 | |
| Snoma (historical) | city | South Dakota | United States | 44.65 | -103.69 | 3349 | |
| Soldier Creek | city | South Dakota | United States | 43.32 | -100.89 | 2509 | |
| Sorum | city | South Dakota | United States | 45.45 | -102.93 | 2798 | |
| Sorum Addition | city | South Dakota | United States | 43.65 | -96.71 | 1669 | |
| Sorum Heights | city | South Dakota | United States | 43.65 | -96.71 | 1669 | |
| South Canyon Country Estates | city | South Dakota | United States | 44.10 | -103.36 | 4189 | |
| South Dakota Park | city | South Dakota | United States | 45.42 | -96.70 | 974 | |
| South Shore | city | South Dakota | United States | 45.11 | -96.93 | 1902 | |
| South Sioux Falls (historical) | city | South Dakota | United States | 43.51 | -96.73 | 1669 | |
| Spain | city | South Dakota | United States | 45.70 | -97.79 | 1669 | |
| Spearfish | city | South Dakota | United States | 44.49 | -103.86 | 3727 | |
| Spencer | city | South Dakota | United States | 43.73 | -97.59 | 1669 | |
| Spink | city | South Dakota | United States | 42.85 | -96.75 | 1227 | |
| Spink Colony | city | South Dakota | United States | 44.75 | -98.29 | 1669 | |
| Split Rock Heights | city | South Dakota | United States | 43.53 | -96.65 | 1669 | |
| Spokane | city | South Dakota | United States | 43.84 | -103.38 | 4432 | |
| Spottswood | city | South Dakota | United States | 44.65 | -98.51 | 1669 | |
| Spring Creek | city | South Dakota | United States | 43.12 | -101.02 | 2798 | |
| Spring Creek Colony | city | South Dakota | United States | 45.91 | -98.88 | 1669 | |
| Spring Grove | city | South Dakota | United States | 45.46 | -97.05 | 1669 | |
| Spring Lake Colony | city | South Dakota | United States | 44.24 | -97.18 | 1751 | |
| Spring Valley | city | South Dakota | United States | 43.20 | -97.27 | 1669 | |
| Spring Valley Colony | city | South Dakota | United States | 44.04 | -98.89 | 1669 | |
| Springfield | city | South Dakota | United States | 42.85 | -97.90 | 1213 | |
| Stamford | city | South Dakota | United States | 43.89 | -101.09 | 2509 | |
| Stanley Corner | city | South Dakota | United States | 43.54 | -97.39 | 1669 | |
| Star Corner (historical) | city | South Dakota | United States | 43.04 | -97.06 | 1669 | |
| State Game Lodge | city | South Dakota | United States | 43.77 | -103.38 | 4416 | |
| Stephan | city | South Dakota | United States | 44.25 | -99.45 | 1801 | |
| Stickney | city | South Dakota | United States | 43.59 | -98.44 | 1669 | |
| Stockholm | city | South Dakota | United States | 45.10 | -96.80 | 1686 | |
| Stone Bridge | city | South Dakota | United States | 44.60 | -97.06 | 1669 | |
| Stoneville | city | South Dakota | United States | 44.73 | -102.65 | 3349 | |
| Storla | city | South Dakota | United States | 43.86 | -98.35 | 1669 | |
| Strandburg | city | South Dakota | United States | 45.04 | -96.76 | 1669 | |
| Stratford | city | South Dakota | United States | 45.32 | -98.30 | 1669 | |
| Stratosphere Bowl | city | South Dakota | United States | 43.98 | -103.35 | 4271 | |
| Strool | city | South Dakota | United States | 45.50 | -102.80 | 2900 | |
| Sturgis | city | South Dakota | United States | 44.41 | -103.51 | 3556 | |
| Success (historical) | city | South Dakota | United States | 44.57 | -97.54 | 1748 | |
| Sulphur | city | South Dakota | United States | 44.88 | -102.91 | 2723 | |
| Summerset | city | South Dakota | United States | 44.19 | -103.34 | 3635 | |
| Summerville | city | South Dakota | United States | 45.77 | -102.18 | 2509 | |
| Summit | city | South Dakota | United States | 45.30 | -97.04 | 1975 | |
| Sundahl Trailer Court | city | South Dakota | United States | 44.34 | -96.78 | 1669 | |
| Sunnyview | city | South Dakota | United States | 44.34 | -96.79 | 1669 | |
| Swanson's Tracts | city | South Dakota | United States | 43.62 | -96.75 | 1669 | |
| Swanson’s Tracts | city | South Dakota | United States | 43.62 | -96.75 | 1669 | |
| Sweetland (historical) | city | South Dakota | United States | 44.34 | -98.98 | 1893 | |
| Swett | city | South Dakota | United States | 43.17 | -101.95 | 3349 | |
| Sylvan Lake Resort | city | South Dakota | United States | 43.85 | -103.56 | 6200 | |
| Sūfolsa | city | South Dakota | United States | 43.55 | -96.70 | 1669 |