| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Sycamore | city | South Carolina | United States | 33.04 | -81.22 | 150 | |
| Sylecope | city | South Carolina | United States | 32.79 | -80.04 | 9 | |
| Sylvan Hills | city | South Carolina | United States | 34.93 | -82.37 | 994 | |
| Sylvia Lane | city | South Carolina | United States | 32.79 | -80.05 | 9 | |
| Syracuse | city | South Carolina | United States | 34.23 | -79.97 | 180 |