| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Liberia | city | South Carolina | United States | 35.01 | -82.63 | 1099 | |
| Liberty | city | South Carolina | United States | 34.79 | -82.69 | 1079 | |
| Liberty Heights | city | South Carolina | United States | 34.32 | -79.86 | 154 | |
| Liberty Hill | city | South Carolina | United States | 34.48 | -80.80 | 410 | |
| Liberty Hill | city | South Carolina | United States | 33.92 | -82.17 | 830 | |
| Liberty Hills | city | South Carolina | United States | 32.88 | -80.00 | 29 | |
| Liberty Park | city | South Carolina | United States | 34.88 | -82.36 | 1000 | |
| Liberty Park | city | South Carolina | United States | 32.89 | -80.02 | 9 | |
| Lickville | city | South Carolina | United States | 34.62 | -82.33 | 866 | |
| Lighthouse Landing | city | South Carolina | United States | 32.18 | -80.74 | 3 | |
| Lighthouse Point | city | South Carolina | United States | 32.73 | -79.92 | 3 | |
| Lima | city | South Carolina | United States | 35.09 | -82.45 | 1099 | |
| Lime Stone (historical) | city | South Carolina | United States | 33.93 | -82.05 | 406 | |
| Limehouse | city | South Carolina | United States | 32.21 | -81.07 | 19 | |
| Limehouse Station | city | South Carolina | United States | 32.77 | -80.08 | 9 | |
| Limerick | city | South Carolina | United States | 33.14 | -79.82 | 19 | |
| Limestone | city | South Carolina | United States | 33.90 | -82.03 | 337 | |
| Limp | city | South Carolina | United States | 33.99 | -81.85 | 830 | |
| Lincoln Estates | city | South Carolina | United States | 35.01 | -81.23 | 830 | |
| Lincoln Green | city | South Carolina | United States | 33.15 | -80.43 | 104 | |
| Lincolnshire | city | South Carolina | United States | 34.09 | -81.03 | 200 | |
| Lincolnville | city | South Carolina | United States | 33.01 | -80.16 | 55 | |
| Lingles Crossroads | city | South Carolina | United States | 34.76 | -80.63 | 830 | |
| Linkside | city | South Carolina | United States | 34.46 | -79.32 | 121 | |
| Lisbon (historical) | city | South Carolina | United States | 34.42 | -82.00 | 830 | |
| Lisbon (historical) | city | South Carolina | United States | 34.04 | -80.81 | 830 | |
| Litchfield Beach | city | South Carolina | United States | 33.47 | -79.10 | 0 | |
| Litchfield Retreat | city | South Carolina | United States | 33.49 | -79.09 | 0 | |
| Litchfield by the Sea | city | South Carolina | United States | 33.48 | -79.10 | 0 | |
| Little Africa | city | South Carolina | United States | 35.17 | -82.03 | 830 | |
| Little Belvidere | city | South Carolina | United States | 33.40 | -80.33 | 111 | |
| Little Chicago | city | South Carolina | United States | 35.06 | -82.18 | 1062 | |
| Little Edisto | city | South Carolina | United States | 32.60 | -80.34 | 6 | |
| Little Hell Landing | city | South Carolina | United States | 33.06 | -81.56 | 78 | |
| Little Mountain | city | South Carolina | United States | 34.20 | -81.41 | 830 | |
| Little Mountain (historical) | city | South Carolina | United States | 34.80 | -79.86 | 265 | |
| Little River | city | South Carolina | United States | 33.87 | -78.61 | 6 | |
| Little River Subdivision | city | South Carolina | United States | 33.85 | -82.37 | 298 | |
| Little Rock | city | South Carolina | United States | 34.48 | -79.40 | 127 | |
| Little Texas | city | South Carolina | United States | 34.97 | -82.40 | 1066 | |
| Little Town | city | South Carolina | United States | 33.96 | -78.74 | 22 | |
| Little Vista Heights | city | South Carolina | United States | 34.94 | -81.91 | 830 | |
| Littleton | city | South Carolina | United States | 34.18 | -81.18 | 200 | |
| Live Oak | city | South Carolina | United States | 34.06 | -78.94 | 98 | |
| Live Oaks | city | South Carolina | United States | 33.55 | -79.05 | 3 | |
| Living Inn | city | South Carolina | United States | 34.11 | -81.46 | 400 | |
| Livingston | city | South Carolina | United States | 33.55 | -81.12 | 298 | |
| Livingston Terrace | city | South Carolina | United States | 33.51 | -80.88 | 226 |