| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Searcy Town | city | Mississippi | United States | 34.82 | -88.49 | 830 | |
| Sebastopol | city | Mississippi | United States | 32.57 | -89.34 | 403 | |
| Self Creek | city | Mississippi | United States | 33.47 | -89.01 | 347 | |
| Sellers | city | Mississippi | United States | 30.59 | -89.36 | 121 | |
| Selma | city | Mississippi | United States | 31.60 | -91.28 | 246 | |
| Sels Prairie | city | Mississippi | United States | 31.94 | -88.63 | 380 | |
| Seminary | city | Mississippi | United States | 31.56 | -89.50 | 209 | |
| Senatobia | city | Mississippi | United States | 34.62 | -89.97 | 288 | |
| Senatobia Lakes | city | Mississippi | United States | 34.62 | -89.88 | 298 | |
| Seneca | city | Mississippi | United States | 31.04 | -89.44 | 305 | |
| Serena Circle Mobile Home Park | city | Mississippi | United States | 31.30 | -89.38 | 357 | |
| Service | city | Mississippi | United States | 31.74 | -89.22 | 242 | |
| Sessions | city | Mississippi | United States | 34.34 | -90.63 | 173 | |
| Sessums | city | Mississippi | United States | 33.42 | -88.71 | 252 | |
| Seven Pines | city | Mississippi | United States | 33.37 | -90.09 | 219 | |
| Seven Springs | city | Mississippi | United States | 32.22 | -90.37 | 396 |