| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| St. Benedict | city | Iowa | United States | 43.04 | -94.06 | 1249 | |
| St. Joseph | city | Iowa | United States | 42.91 | -94.23 | 1112 | |
| Stacyville | city | Iowa | United States | 43.44 | -92.78 | 1210 | |
| Stacyville Junction | city | Iowa | United States | 43.45 | -92.93 | 1187 | |
| Stanhope | city | Iowa | United States | 42.29 | -93.80 | 1128 | |
| Stanley | city | Iowa | United States | 42.64 | -91.81 | 1089 | |
| Stanton | city | Iowa | United States | 40.98 | -95.10 | 1148 | |
| Stanwood | city | Iowa | United States | 41.89 | -91.15 | 908 | |
| Stanzel | city | Iowa | United States | 41.32 | -94.26 | 1253 | |
| Starlite Mobile Home Park | city | Iowa | United States | 42.01 | -92.92 | 984 | |
| State Center | city | Iowa | United States | 42.02 | -93.16 | 1066 | |
| State Center Junction | city | Iowa | United States | 41.94 | -93.05 | 1049 | |
| Steamboat Rock | city | Iowa | United States | 42.41 | -93.07 | 1030 | |
| Stein's Rockin R Mobile Home Park | city | Iowa | United States | 42.73 | -94.44 | 1220 | |
| Stennett | city | Iowa | United States | 41.09 | -95.19 | 1174 | |
| Sterling | city | Iowa | United States | 42.08 | -90.25 | 830 | |
| Steuben | city | Iowa | United States | 40.72 | -92.39 | 862 | |
| Stevens | city | Iowa | United States | 43.43 | -94.00 | 1197 | |
| Stiles | city | Iowa | United States | 40.64 | -92.35 | 859 | |
| Stillwell | city | Iowa | United States | 41.52 | -92.67 | 830 | |
| Stilson | city | Iowa | United States | 43.04 | -93.89 | 1204 | |
| Stimsons (historical) | city | Iowa | United States | 42.35 | -94.60 | 1194 | |
| Stockport | city | Iowa | United States | 40.86 | -91.84 | 830 | |
| Stockton | city | Iowa | United States | 41.59 | -90.86 | 830 | |
| Stone City | city | Iowa | United States | 42.11 | -91.35 | 830 | |
| Stonega | city | Iowa | United States | 42.48 | -93.71 | 1200 | |
| Storm Lake | city | Iowa | United States | 42.64 | -95.21 | 1669 | |
| Story City | city | Iowa | United States | 42.19 | -93.60 | 994 | |
| Stout | city | Iowa | United States | 42.53 | -92.71 | 1049 | |
| Stover Heights Community | city | Iowa | United States | 41.64 | -93.56 | 849 | |
| Strahan | city | Iowa | United States | 40.95 | -95.50 | 1148 | |
| Strand | city | Iowa | United States | 41.07 | -94.90 | 1105 | |
| Stratford | city | Iowa | United States | 42.27 | -93.93 | 1108 | |
| Strawberry Point | city | Iowa | United States | 42.68 | -91.53 | 1210 | |
| Streepy | city | Iowa | United States | 40.70 | -92.92 | 1003 | |
| Stringtown | city | Iowa | United States | 40.98 | -94.56 | 1669 | |
| Struble | city | Iowa | United States | 42.90 | -96.20 | 1249 | |
| Stuart | city | Iowa | United States | 41.50 | -94.32 | 1200 |