| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Sa Martín de Trevellu | city | Extremadura | Spain | 40.21 | -6.80 | 3349 | 2181 |
| Salorino | city | Extremadura | Spain | 39.48 | -7.01 | 1013 | 478 |
| Salvaleón | city | Extremadura | Spain | 38.51 | -6.79 | 1912 | 2615 |
| Salvatierra | city | Extremadura | Spain | 38.49 | -6.68 | 1971 | 2133 |
| Salvatierra de Santiago | city | Extremadura | Spain | 39.30 | -6.03 | 1669 | 1097 |
| Salvatierra de los Barros | city | Extremadura | Spain | 38.49 | -6.68 | 1971 | 2133 |
| San Andrés | city | Extremadura | Spain | 40.27 | -5.87 | 2693 | 4408 |
| San Benito de la Contienda | city | Extremadura | Spain | 38.63 | -7.16 | 830 | 1966 |
| San Isidro | city | Extremadura | Spain | 38.53 | -6.35 | 1669 | 10224 |
| San Jorge | city | Extremadura | Spain | 38.64 | -7.06 | 895 | 3975 |
| San Martiño de Trebello | city | Extremadura | Spain | 40.21 | -6.80 | 3349 | 2181 |
| San Martín de Trevejo | city | Extremadura | Spain | 40.21 | -6.80 | 3349 | 2181 |
| San Pedro | city | Extremadura | Spain | 39.37 | -7.29 | 1669 | 1248 |
| San Pedro de Merida | city | Extremadura | Spain | 38.95 | -6.19 | 830 | 3026 |
| San Roque | city | Extremadura | Spain | 38.88 | -6.96 | 830 | 26442 |
| San Vicente de Alcántara | city | Extremadura | Spain | 39.36 | -7.14 | 1669 | 1493 |
| Sancti Spiritus | city | Extremadura | Spain | 38.93 | -5.15 | 1699 | 949 |
| Santa Amalia | city | Extremadura | Spain | 39.01 | -6.01 | 830 | 6512 |
| Santa Ana | city | Extremadura | Spain | 38.65 | -6.48 | 1089 | 11369 |
| Santa Ana | city | Extremadura | Spain | 39.31 | -5.99 | 1669 | 1004 |
| Santa Cruz de Paniagua | city | Extremadura | Spain | 40.19 | -6.34 | 1669 | 784 |
| Santa Cruz de la Sierra | city | Extremadura | Spain | 39.34 | -5.85 | 1669 | 944 |
| Santa Elena | city | Extremadura | Spain | 38.27 | -6.03 | 1994 | 2316 |
| Santa Engracia | city | Extremadura | Spain | 38.91 | -6.98 | 830 | 20783 |
| Santa Maria | city | Extremadura | Spain | 39.51 | -6.10 | 1227 | 1266 |
| Santa Maria | city | Extremadura | Spain | 38.53 | -5.73 | 1728 | 933 |
| Santa Marta | city | Extremadura | Spain | 38.61 | -6.63 | 1131 | 2797 |
| Santa Marta | city | Extremadura | Spain | 39.51 | -6.10 | 1227 | 1266 |
| Santa Marta de Magasca | city | Extremadura | Spain | 39.51 | -6.10 | 1227 | 1266 |
| Santa María de Nava la Zapatera | city | Extremadura | Spain | 38.02 | -6.08 | 1669 | 1135 |
| Santiago de Carbajo | city | Extremadura | Spain | 39.61 | -7.24 | 1669 | 781 |
| Santiago del Campo | city | Extremadura | Spain | 39.63 | -6.36 | 1181 | 821 |
| Santibáñez el Alto | city | Extremadura | Spain | 40.19 | -6.55 | 1669 | 1509 |
| Santibáñez el Bajo | city | Extremadura | Spain | 40.18 | -6.22 | 1148 | 2252 |
| Santo Domingo | city | Extremadura | Spain | 38.38 | -6.47 | 1669 | 7243 |
| Santo Domingo | city | Extremadura | Spain | 38.63 | -7.09 | 1669 | 3244 |
| Sauceda | city | Extremadura | Spain | 40.30 | -6.36 | 1669 | 1265 |
| Saucedilla | city | Extremadura | Spain | 39.85 | -5.68 | 915 | 1568 |
| Segura de León | city | Extremadura | Spain | 38.12 | -6.52 | 2509 | 2091 |
| Segura de Toro | city | Extremadura | Spain | 40.22 | -5.95 | 2670 | 2482 |
| Serradilla | city | Extremadura | Spain | 39.83 | -6.14 | 1207 | 808 |
| Serrejon | city | Extremadura | Spain | 39.82 | -5.80 | 1148 | 417 |
| Sevillano | city | Extremadura | Spain | 39.07 | -5.39 | 1135 | 1019 |
| Sierra Gorda | city | Extremadura | Spain | 38.43 | -6.54 | 1738 | 1858 |
| Sierra Santa Olalla | city | Extremadura | Spain | 40.14 | -6.78 | 2063 | 1278 |
| Sierra de Fuentes | city | Extremadura | Spain | 39.44 | -6.27 | 1669 | 8593 |
| Siruela | city | Extremadura | Spain | 38.98 | -5.05 | 1765 | 1107 |
| Sobrante Berrocal | city | Extremadura | Spain | 38.90 | -5.73 | 1089 | 2165 |
| Solana | city | Extremadura | Spain | 38.73 | -6.54 | 830 | 3700 |
| Solana | city | Extremadura | Spain | 39.48 | -5.48 | 3349 | 626 |
| Solana de los Barros | city | Extremadura | Spain | 38.73 | -6.54 | 830 | 3700 |
| Soledad | city | Extremadura | Spain | 38.65 | -6.47 | 1131 | 12579 |