| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Sabanita | city | Colon | Panama | 9.34 | -79.81 | 131 | 42923 |
| Sabanita Verde | city | Colon | Panama | 8.90 | -80.44 | 104 | 1857 |
| Sabanitas | city | Colon | Panama | 9.34 | -79.81 | 131 | 42923 |
| Salamanca | city | Colon | Panama | 9.34 | -79.60 | 308 | 5224 |
| Salamanquita | city | Colon | Panama | 9.34 | -79.59 | 337 | 6711 |
| Salato | city | Colon | Panama | 9.58 | -79.42 | 6 | 387 |
| Salsipuedes | city | Colon | Panama | 9.19 | -80.17 | 49 | 1696 |
| Salud | city | Colon | Panama | 9.20 | -80.13 | 52 | 1976 |
| Salud Número Uno | city | Colon | Panama | 9.20 | -80.13 | 52 | 1976 |
| Samba Bonita | city | Colon | Panama | 9.37 | -79.85 | 72 | 34369 |
| Sambalamba | city | Colon | Panama | 9.37 | -79.85 | 72 | 34369 |
| San Antonio | city | Colon | Panama | 9.56 | -79.56 | 134 | 2149 |
| San Jose | city | Colon | Panama | 8.96 | -80.31 | 337 | 1707 |
| San Juan de Turbe | city | Colon | Panama | 8.78 | -80.62 | 265 | 1675 |
| San Lucas | city | Colon | Panama | 9.00 | -80.56 | 298 | 748 |
| Santa Elena | city | Colon | Panama | 9.57 | -79.63 | 187 | 1852 |
| Santa Fe | city | Colon | Panama | 9.25 | -80.08 | 29 | 1323 |
| Santa Fe Arriba | city | Colon | Panama | 9.09 | -80.07 | 269 | 1991 |
| Santa Fé Abajo | city | Colon | Panama | 9.11 | -80.08 | 137 | 2482 |
| Santa Isabel | city | Colon | Panama | 9.54 | -79.19 | 22 | 397 |
| Santa Isabel | city | Colon | Panama | 9.57 | -79.63 | 187 | 1852 |
| Santa Librada | city | Colon | Panama | 9.40 | -79.56 | 830 | 7250 |
| Santa Marta | city | Colon | Panama | 9.25 | -80.07 | 104 | 1487 |
| Santa Rita | city | Colon | Panama | 9.02 | -79.98 | 118 | 2855 |
| Santa Rita | city | Colon | Panama | 9.32 | -79.78 | 314 | 30528 |
| Santa Rita | city | Colon | Panama | 9.33 | -79.79 | 830 | 38276 |
| Santa Rita Arriba | city | Colon | Panama | 9.33 | -79.79 | 830 | 38276 |
| Santa Rosa | city | Colon | Panama | 9.05 | -80.20 | 111 | 2216 |
| Santa Rosa | city | Colon | Panama | 9.18 | -79.65 | 121 | 39337 |
| Santa Rosa | city | Colon | Panama | 9.23 | -80.10 | 13 | 1601 |
| Santo Domingo | city | Colon | Panama | 9.39 | -79.61 | 1213 | 3106 |
| Sardina | city | Colon | Panama | 8.80 | -80.57 | 183 | 1686 |
| Sardinilla | city | Colon | Panama | 9.30 | -79.64 | 206 | 23393 |
| Sardinilla | city | Colon | Panama | 9.30 | -79.64 | 206 | 23393 |
| Sherman | city | Colon | Panama | 9.37 | -79.96 | 26 | 4824 |
| Siban | city | Colon | Panama | 9.40 | -79.75 | 830 | 10734 |
| Sierra Llorona | city | Colon | Panama | 9.36 | -79.70 | 1669 | 4905 |
| Silver City | city | Colon | Panama | 9.33 | -79.89 | 45 | 39206 |
| Solís | city | Colon | Panama | 8.97 | -80.55 | 219 | 933 |