| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Iguapa | city | Barima-Waini | Guyana | 7.40 | -59.27 | 830 | 149 |
| Igupa Village | city | Barima-Waini | Guyana | 7.40 | -59.27 | 830 | 149 |
| Illimir Village | city | Upper Takutu-Upper Essequibo | Guyana | 2.27 | -59.45 | 918 | 0 |
| Imbaimadai | city | Cuyuni-Mazaruni | Guyana | 5.70 | -60.28 | 1669 | 0 |
| Imprenza | city | Upper Takutu-Upper Essequibo | Guyana | 3.13 | -59.83 | 364 | 0 |
| Indiana | city | Pomeroon-Supenaam | Guyana | 6.91 | -58.68 | 32 | 805 |
| Indina | city | Pomeroon-Supenaam | Guyana | 6.91 | -58.68 | 32 | 805 |
| Inkapati | city | Upper Takutu-Upper Essequibo | Guyana | 4.13 | -58.47 | 272 | 0 |
| Invincible | city | Barima-Waini | Guyana | 7.60 | -60.40 | 288 | 149 |
| Ipichau | city | Potaro-Siparuni | Guyana | 4.88 | -60.02 | 2007 | 88 |
| Ipisháu | city | Potaro-Siparuni | Guyana | 4.88 | -60.02 | 2007 | 88 |
| Ipisiau Village | city | Potaro-Siparuni | Guyana | 4.88 | -60.02 | 2007 | 88 |
| Ipotaikuru | city | Barima-Waini | Guyana | 7.43 | -59.60 | 108 | 149 |
| Ishalton | city | Upper Takutu-Upper Essequibo | Guyana | 2.52 | -59.25 | 987 | 0 |
| Isherton | city | Upper Takutu-Upper Essequibo | Guyana | 2.32 | -59.37 | 1669 | 0 |
| Islington | city | East Berbice-Corentyne | Guyana | 6.22 | -57.52 | 3 | 25796 |
| Issano | city | Cuyuni-Mazaruni | Guyana | 5.81 | -59.42 | 101 | 0 |
| Issano Terminus | city | Cuyuni-Mazaruni | Guyana | 5.81 | -59.42 | 101 | 0 |
| Isseneru Village | city | Cuyuni-Mazaruni | Guyana | 6.47 | -60.33 | 830 | 0 |
| Issororo | city | Barima-Waini | Guyana | 8.18 | -59.80 | 55 | 545 |
| Issororo | city | Pomeroon-Supenaam | Guyana | 7.25 | -58.88 | 249 | 894 |
| Itabac | city | Potaro-Siparuni | Guyana | 4.60 | -60.10 | 1824 | 62 |
| Itabu Quarry | city | Cuyuni-Mazaruni | Guyana | 6.37 | -58.68 | 3 | 2268 |
| Itaka | city | Essequibo Islands-West Demerara | Guyana | 6.57 | -58.57 | 3 | 177 |
| Itaki | city | Cuyuni-Mazaruni | Guyana | 5.97 | -59.18 | 82 | 0 |
| Ithaca | city | Essequibo Islands-West Demerara | Guyana | 6.57 | -58.57 | 3 | 177 |
| Itoni Township | city | Upper Demerara-Berbice | Guyana | 5.54 | -58.26 | 331 | 0 |
| Ituni | city | Upper Demerara-Berbice | Guyana | 5.54 | -58.26 | 331 | 0 |
| Ituni Townsite | city | Upper Demerara-Berbice | Guyana | 5.54 | -58.26 | 331 | 0 |