| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Sabanaso | city | Choco | Colombia | 7.24 | -77.19 | 147 | 447 |
| Salaqui | city | Choco | Colombia | 7.30 | -77.55 | 1112 | 447 |
| Salto del Mico | city | Choco | Colombia | 7.42 | -76.99 | 177 | 447 |
| Samurindo | city | Choco | Colombia | 5.59 | -76.65 | 282 | 1788 |
| San Agustín | city | Choco | Colombia | 4.75 | -76.82 | 203 | 1854 |
| San Francisco | city | Choco | Colombia | 8.36 | -77.11 | 59 | 951 |
| San Francisco de Quibdó | city | Choco | Colombia | 5.69 | -76.66 | 232 | 38818 |
| San Geronimo | city | Choco | Colombia | 8.45 | -77.27 | 55 | 1190 |
| San Jerónimo | city | Choco | Colombia | 4.96 | -76.61 | 393 | 3082 |
| San Jerónimo | city | Choco | Colombia | 8.45 | -77.27 | 55 | 1190 |
| San Jose de Purre | city | Choco | Colombia | 5.63 | -76.53 | 830 | 1788 |
| San Jose del Palmar | city | Choco | Colombia | 4.97 | -76.23 | 9228 | 1365 |
| San Lorenzo | city | Choco | Colombia | 4.98 | -76.64 | 351 | 1240 |
| San Marino | city | Choco | Colombia | 5.39 | -76.34 | 843 | 3139 |
| San Martin de Purre | city | Choco | Colombia | 5.75 | -76.63 | 272 | 14155 |
| San Martín | city | Choco | Colombia | 5.75 | -76.63 | 272 | 14155 |
| San Miguel | city | Choco | Colombia | 4.80 | -76.87 | 183 | 3070 |
| San Miguel | city | Choco | Colombia | 8.45 | -77.27 | 55 | 1190 |
| San Pablito | city | Choco | Colombia | 4.67 | -76.73 | 278 | 395 |
| San Pablo | city | Choco | Colombia | 5.20 | -76.67 | 265 | 13585 |
| San Pablo Adentro | city | Choco | Colombia | 5.20 | -76.67 | 265 | 13585 |
| San Pedro de Ingará | city | Choco | Colombia | 4.92 | -76.37 | 4189 | 1156 |
| Santa Ana | city | Choco | Colombia | 5.11 | -76.52 | 830 | 1490 |
| Santa Barbara | city | Choco | Colombia | 5.17 | -76.48 | 830 | 1754 |
| Santa Genoveva de Docorodó | city | Choco | Colombia | 4.26 | -77.37 | 3 | 298 |
| Santa Maria | city | Choco | Colombia | 8.22 | -77.02 | 6 | 1495 |
| Santa Maria La Nueva | city | Choco | Colombia | 8.17 | -77.05 | 91 | 1788 |
| Santa María | city | Choco | Colombia | 8.17 | -77.05 | 91 | 1788 |
| Santa María Del Darién | city | Choco | Colombia | 8.17 | -77.05 | 91 | 1788 |
| Santa María La Antigua | city | Choco | Colombia | 8.22 | -77.02 | 6 | 1495 |
| Santa Rita | city | Choco | Colombia | 5.18 | -76.48 | 383 | 1910 |
| Santa Rosa | city | Choco | Colombia | 4.97 | -76.66 | 341 | 1225 |
| Sapsurro | city | Choco | Colombia | 8.66 | -77.37 | 364 | 723 |
| Sapzurro | city | Choco | Colombia | 8.66 | -77.37 | 364 | 723 |
| Sautatá | city | Choco | Colombia | 7.84 | -77.13 | 72 | 846 |
| Secundino Perea | city | Choco | Colombia | 5.02 | -77.12 | 85 | 2144 |
| Selva | city | Choco | Colombia | 4.92 | -76.15 | 9583 | 9713 |
| Sesego | city | Choco | Colombia | 4.99 | -76.57 | 830 | 3462 |
| Sicuela | city | Choco | Colombia | 7.41 | -77.11 | 3 | 7925 |
| Sipí | city | Choco | Colombia | 4.66 | -76.48 | 3579 | 561 |
| Sivira | city | Choco | Colombia | 4.80 | -77.34 | 0 | 233 |
| Sivirú | city | Choco | Colombia | 4.80 | -77.34 | 0 | 233 |
| Soledad | city | Choco | Colombia | 5.03 | -76.53 | 1811 | 1311 |
| Suroco | city | Choco | Colombia | 5.10 | -76.77 | 347 | 3129 |
| Suruco | city | Choco | Colombia | 5.10 | -76.77 | 347 | 3129 |